Protection against Malaria by MSP3 Candidate Vaccine
نویسندگان
چکیده
منابع مشابه
Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.
BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine),...
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BACKGROUND MSP3 has been shown to induce protection against malaria in African children. The characterization of a family of Plasmodium falciparum merozoite surface protein 3 (MSP3) antigens sharing a similar structural organization, simultaneously expressed on the merozoite surface and targeted by a cross-reactive network of protective antibodies, is intriguing and offers new perspectives for ...
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BACKGROUND A Phase Ia trial in European volunteers of the candidate vaccine merozoite surface protein 3 (MSP3), a Plasmodium falciparum blood stage membrane, showed that it induces biologically active antibodies able to achieve parasite killing in vitro, while a phase Ib trial in semi-immune adult volunteers in Burkina Faso confirmed that the vaccine was safe. The aim of this study was to asses...
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We have shown that the haemolytic activity of fatty acids may be implicated in the destruction of erythrocytes by malaria parasites (Laser et al., 1975a,b). Under normal conditions free fatty acids are buffered by albumin in the serum and haemoglobin within the erythrocyte. During a malarial infection, however, the presence of the Plasmodium leads to an increase in both serum and erythrocyte fa...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2011
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmc1100670